MovDisordV3, Main, Exploration, bibRecord, 004F11

Rarity of debrisoquine hydroxylase gene polymorphism in chinese patients with Parkinson's disease

Identifieur interne : 004F11 ( Main/Exploration ); précédent : 004F10; suivant : 004F12

Rarity of debrisoquine hydroxylase gene polymorphism in chinese patients with Parkinson's disease

Auteurs : Pang [Hong Kong] ; Jun Zhang [Hong Kong] ; Jean Woo [Hong Kong] ; Daniel Chan [Hong Kong] ; Lap K. Law [Hong Kong] ; Shirley F. Tong [Hong Kong] ; Timothy Kwok [Hong Kong] ; Richard Kay [Hong Kong]

Source :

Movement Disorders [ 0885-3185 ] ; 1998-05.

RBID : ISTEX:19D28F2451F1C54AE481F3EBC99A3BFB1493AD7F

Descripteurs français

Wicri :
- geographic : Hong Kong.

English descriptors

KwdEn :
- Aged, CYP2D6 polymorphism, Chinese, Cytochrome P-450 CYP2D6 (genetics), Ethnic Groups (genetics), Female, Heterozygote Detection, Hong Kong, Humans, Male, Middle Aged, Parkinson Disease (enzymology), Parkinson Disease (genetics), Parkinson's disease, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Risk.
MESH :
- chemical , genetics : Cytochrome P-450 CYP2D6.
- geographic : Hong Kong.
- enzymology : Parkinson Disease.
- genetics : Ethnic Groups, Parkinson Disease.
- Aged, Female, Heterozygote Detection, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Risk.

Abstract

Impaired debrisoquine metabolism resulting from defects in the cytochrome P450 CYP2D6‐debrisoquine hydroxylase gene has been shown to be associated with the development of Parkinson's disease(PD). We studied two polymorphisms in this gene in 207 Chinese PD patients and 227 control subjects by polymerase chain reaction and restriction analysis. The G to A substitution at position 1934 in the junction of intron 3/exon 4 was detected in one sporadic PD patient and two control subjects, all of whom were heterozygous. The single base deletion at position 2637 in exon 5 was not detected in any of the study subjects. Such rarity of CYP2D6 polymorphism indicates PD in the Chinese population is associated with some other gene defects.

Url:

https://api.istex.fr/document/19D28F2451F1C54AE481F3EBC99A3BFB1493AD7F/fulltext/pdf

DOI: 10.1002/mds.870130324

Affiliations:

Le document en format XML

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<author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name>
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<author><name sortKey="Woo, Jean" sort="Woo, Jean" uniqKey="Woo J" first="Jean" last="Woo">Jean Woo</name>
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<author><name sortKey="Chan, Daniel" sort="Chan, Daniel" uniqKey="Chan D" first="Daniel" last="Chan">Daniel Chan</name>
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<term>Parkinson Disease (genetics)</term>
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<front><div type="abstract" xml:lang="en">Impaired debrisoquine metabolism resulting from defects in the cytochrome P450 CYP2D6‐debrisoquine hydroxylase gene has been shown to be associated with the development of Parkinson's disease(PD). We studied two polymorphisms in this gene in 207 Chinese PD patients and 227 control subjects by polymerase chain reaction and restriction analysis. The G to A substitution at position 1934 in the junction of intron 3/exon 4 was detected in one sporadic PD patient and two control subjects, all of whom were heterozygous. The single base deletion at position 2637 in exon 5 was not detected in any of the study subjects. Such rarity of CYP2D6 polymorphism indicates PD in the Chinese population is associated with some other gene defects.</div>
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Movement Disorders (revue)

Rarity of debrisoquine hydroxylase gene polymorphism in chinese patients with Parkinson's disease

Rarity of debrisoquine hydroxylase gene polymorphism in chinese patients with Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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